Bilbao has shrugged off its grimy industrial past and has transformed itself into one of Spain's trendiest weekend break destinations. More down to earth than Barcelona and with more culture than Marbella, this is a corner of Northern Spain with a lot to offer. Explore the narrow streets of the Casco Viejo or Old Town for top-notch tapas and the best bars – but remember that things don't really get started until after midnight so have a siesta and stay out late like the locals. If you're more into culture than cocktails, the Guggenheim Museum will be right up your street with both a permanent display and temporary exhibitions of modern art. Bilbao's a compact city which makes strolling a pleasure, with the risk that you'll be tempted to stop at yet another gorgeous shop or innovative Basque restaurant along the way. Round off your weekend with a glass of txakoli, the local sparkling wine, as you people watch from a pavement cafe.